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Onset time of Ca antagonistic action of CD-349 in comparison with other dihydropyridine compounds
https://dwcla.repo.nii.ac.jp/records/405
https://dwcla.repo.nii.ac.jp/records/405c9ef33fb-96a6-49b3-99f9-87a64c6eca69
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-26 | |||||
| タイトル | ||||||
| タイトル | Onset time of Ca antagonistic action of CD-349 in comparison with other dihydropyridine compounds | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dihydropyridine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ca antagonist | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ca current | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tissue distribution | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | myocardium | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
土田, 勝晴
× 土田, 勝晴× WATAJIMA, Hiroshi× OGAWA, Naoyoshi× TSUCHIDA, Katsuharu× WATAJIMA, Hiroshi× OGAWA, Naoyoshi |
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| 著者 所属 | ||||||
| 値 | 同志社女子大学薬学部医療薬学科 | |||||
| 著者 所属 | ||||||
| 値 | Research Center, Taisho Pharmaceutical Co．, Ltd | |||||
| 著者 所属 | ||||||
| 値 | Research Center, Taisho Pharmaceutical Co．, Ltd | |||||
| 著者所属(翻訳) | ||||||
| 値 | Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy | |||||
| 著者 役割 | ||||||
| 値 | Author | |||||
| 著者 役割 | ||||||
| 値 | Collaborator | |||||
| 著者 役割 | ||||||
| 値 | Collaborator | |||||
| 著者 外部リンク | ||||||
| 表示名 | 同志社女子大学研究者データベース - 土田勝晴 | |||||
| URL | http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2701/2701_Researcher.html | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the relationship between the tissue distribution and the time of onset of the calcium antagonistic action of CD-349 in comparison with nicardipine and nitrendipine. CD-349 has a vasodilatory actionappearing more slowly than nicardipine when administered intravenously. The binding rate to the L-type calcium channels for CD-349 is much higher tha that for nitrendipine in the crude membrane preparation, whereas the uptake of CD-349 into tissue was somewhat slower tha that of nitrendipine in bovine vessels. The results of the present study showed that the distribution intu tissues and the release from the tissues occurred more slowly with CD-349 than with nicardipine in cardiac, vascular and skeletal muscular tissues. In addition, the present study revealed tha CD-349 and nitrendipine inhibited the L-type Ca current in single ventricular myocytes in a similar manner with time. The results of the tissue distribution and release study explained well the time to reach the maximal effects of CD-349 and nicardipine, and the present electropharmacological study demonstrated that the time of onset to exert Ca antagonistic actions of dihydropyridine compounds is completely dependent on the rate of drug diffusion into tissues but not the channel binfing rate even in isolated single cells. It is concluded that the tissue distribution is critically important for dihydropyridines to access Ca channels. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文 (Article) | |||||
| 書誌情報 |
同志社女子大學學術研究年報 en : Doshisha Women's College of Liberal Arts annual reports of studies 巻 58, p. 77-83, 発行日 2007-12-26 |
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| 出版地 | ||||||
| 出版者 | 京都 | |||||
| 出版者 | ||||||
| 出版者 | 同志社女子大学学術研究推進センター | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 04180038 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0016561X | |||||
| ID | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | AN0016561X-20071226-77 | |||||
