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カチオン性・両親媒性薬物 (CAD) の肝細胞への取り込み機構 : 能動輸送システムを仮定したコンパートメントモデルによるシミュレイション
https://dwcla.repo.nii.ac.jp/records/759
https://dwcla.repo.nii.ac.jp/records/759e37014e2-c016-499e-9cc8-dbf2c7e0181a
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-08 | |||||
| タイトル | ||||||
| タイトル | カチオン性・両親媒性薬物 (CAD) の肝細胞への取り込み機構 : 能動輸送システムを仮定したコンパートメントモデルによるシミュレイション | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 別タイトル | ||||||
| その他のタイトル | Mechanism for hepatic-cellular uptake of cationic amphiphilic drugs : compartmental model analysis assuming active transport systems | |||||
| 著者 |
伊賀, 勝美
× 伊賀, 勝美× IGA, Katsumi |
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| 著者 所属 | ||||||
| 値 | 同志社女子大学薬学部医療薬学科 | |||||
| 著者所属(翻訳) | ||||||
| 値 | Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy | |||||
| 著者 外部リンク | ||||||
| 表示名 | 同志社女子大学研究者データベース - 伊賀勝美 | |||||
| URL | http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2691/2691_Researcher.html | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hallifax and Houston have reported that cationic amphiphilic drugs such as quinine, propranolol, imipramine, fluvoxamine, and fluoxetin were taken up by rat hepatic cells both in saturable and non-saturable manners in in-vitro cellular uptake experiments. In this study, the reported profiles of the cellular uptake rate versus applied drug concerntration were simulated using a compartmental model, assuming eight compartments representing intra-cellular organelle and active transport systems on cellular membranes. When it was assumed that an ionized molecule can be distributed into the lipid membranes (partition coefficient, P(i)) and that this ionized molecule can be transported into the cytosolic and lysosomal spaces by transporters expressed on the cellurar membrane and lysosomal membrane, respectively, the actual cellular uptake rate profiles were simulated successfully. It was also found that the non-saturable distributions that had been reported to differ greatly among ths CADs were determined almost entirely by P(i) and that there was a strong correlation between P(i) nad pKa. The ratios of the maximal cytosolic drug concentration to the incubation medium (f2/1, max) estimated for the CADs after the sumulations, to which attention should be paid in relation to the drug-drug interaction potential of metabolic inhibitors, accounted for a significantly high value ranging from 4 to 7. The value estimated for fluvoxamine (approximately 7) seemed to help explain the unusually large magnitudes of drug-drug interactions found in the concomitant administrations with fluvoxamine. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文 (Article) | |||||
| 書誌情報 |
総合文化研究所紀要 en : Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts 巻 30, p. 77-92, 発行日 2013-07-08 |
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| 出版地 | ||||||
| 出版者 | 京都 | |||||
| 出版者 | ||||||
| 出版者 | 同志社女子大学総合文化研究所 (教育・研究推進センター) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09100105 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10052143 | |||||
| 論文ID（NAID） | ||||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 40019835698 | |||||
| ID | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | AN10052143-20130708-77 | |||||
