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難吸収性薬物の吸収性に関する評価基準とそれに基づく製剤設計
https://dwcla.repo.nii.ac.jp/records/723
https://dwcla.repo.nii.ac.jp/records/7234415eb18-1fdc-4293-baf1-3ec78804bb37
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-31 | |||||
| タイトル | ||||||
| タイトル | 難吸収性薬物の吸収性に関する評価基準とそれに基づく製剤設計 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 別タイトル | ||||||
| その他のタイトル | Evaluation criteria for the intestinal absorption of compounds exhibiting poor aqueous solubility and design of dosage forms based upon those criteria | |||||
| 著者 |
伊賀, 勝美
× 伊賀, 勝美× IGA, Katsumi |
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| 著者 所属 | ||||||
| 値 | 同志社女子大学薬学部医療薬学科 | |||||
| 著者所属(翻訳) | ||||||
| 値 | Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy | |||||
| 著者 外部リンク | ||||||
| 表示名 | 同志社女子大学研究者データベース - 伊賀勝美 | |||||
| URL | http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2691/2691_Researcher.html | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Simulating an intestinal drug absorption rate through a model incorporating rates of dissolution and absorption allowed me to demonstrate that incomplete absorption of drugs exhibiting low aqueous solubility occurs because of the saturation of drug dissolution while the dose transits through the small intestine: the overall absorption rate is independent of the drug dissolution rate and can be calculated by an immediate-dissolution rate model. Using this simple model, we can place the four drug classes as defined by the Biopharmaceutics Classification System (BCS) into the absorption-rate matrix represented by the dose number divided by the aqueous-solubility number, taking the intestinal-fluidvolume number as the vertical coordinate, the product of the first-order absorption rate as the constant, and the small intestinal-transit time as the cross coordinate. I was also able to demonstrate that improving the absorption rate of a compound exhibiting incomplete absorption is achievable only by increasing its aqueous solubility through solid-dispersion or lipid formulations and will not occur after a nano-size reduction of the drug powders. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文 (Article) | |||||
| 書誌情報 |
総合文化研究所紀要 en : Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts 巻 28, p. 80-92, 発行日 2011-03-31 |
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| 出版地 | ||||||
| 出版者 | 京都 | |||||
| 出版者 | ||||||
| 出版者 | 同志社女子大学総合文化研究所 (教育・研究推進センター) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09100105 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10052143 | |||||
| 論文ID（NAID） | ||||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 40018944261 | |||||
| ID | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | AN10052143-20110331-80 | |||||
