{"created":"2023-05-15T14:05:51.887395+00:00","id":709,"links":{},"metadata":{"_buckets":{"deposit":"fbf890ab-20b7-4d49-b820-ded341b3e975"},"_deposit":{"created_by":15,"id":"709","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"709"},"status":"published"},"_oai":{"id":"oai:dwcla.repo.nii.ac.jp:00000709","sets":["20:21","224:230"]},"author_link":["1229","1220","1709","1225","950","919"],"item_10002_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Quinoid polycyclic aromatic hydrocarbons-mediated production of reactive oxygen species and subsequet activation of NF-κB and induction of cyclooxygenase-2"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"155","bibliographicPageStart":"149","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"総合文化研究所紀要"},{"bibliographic_title":"Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts","bibliographic_titleLang":"en"}]}]},"item_10002_description_19":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10002_description_35":{"attribute_name":"ID","attribute_value_mlt":[{"subitem_description":"AN10052143-20100331-149","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tobacco smoke and the atmosphere consist of a wide variety of compounds with adverse health effects. Polycyclic aromatic hydrocarbons (PAHs) are principal toxic compounds. Some of PAHs containing oxygen (quinoid PAHs) generate reactive oxygen species (ROS) through enzymatic and nonenzymatic redox cycling reactions. ROS can cause severe oxidative stress leading to various diseases such as cancer and inflammation. In this study, we estimated the intracellular ROS production and nuclear factor kappa B (NF-κB) translocation in A549 cells exposed to isomers of quinoid PAHs having two to four rings. We found that both acenaphthenequinone (AcQ) and phenanthrene-9,10-quinone (PQ) enhanced ROS generation and that AcQ translocated NF-κB from the cytosol to the nucleus. In addition, AcQ induced cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) production were mediated by the activation of NF-κB. Upregulation of NF-κB and COX-2 expression and PGE2 production by AcQ treatment was suppressed by the antioxidant N-acetylcysteine. These results provide that AcQ might play an important role in human lung cancer and inflammatory diseases.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究ノート (Note)","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15020/00000696","subitem_identifier_reg_type":"JaLC"}]},"item_10002_link_30":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_link_text":"同志社女子大学研究者データベース - 木津良一","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2692/2692_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 眞田法子","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2721/2721_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 木下由佳","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/3038/3038_Researcher.html"}]},"item_10002_publisher_32":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_publisher":"京都"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社女子大学総合文化研究所 (教育・研究推進センター)"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"120002857734","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10052143","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09100105","subitem_source_identifier_type":"ISSN"}]},"item_10002_text_27":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"同志社女子大学薬学部医療薬学科"},{"subitem_text_value":"同志社女子大学薬学部医療薬学科"},{"subitem_text_value":"同志社女子大学薬学部医療薬学科"}]},"item_10002_text_28":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences , Department of Clinical Pharmacy"},{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences , Department of Clinical Pharmacy"},{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences , Department of Clinical Pharmacy"}]},"item_10002_text_29":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"Author"},{"subitem_text_value":"Collaborator"},{"subitem_text_value":"Collaborator"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木津, 良一"},{"creatorName":"キヅ, リョウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"眞田, 法子"},{"creatorName":"サナダ, ノリコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"後藤, 由佳"},{"creatorName":"ゴトウ, ユカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KIZU, Ryoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SANADA, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GOTOH, Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1709","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-08-05"}],"displaytype":"detail","filename":"AN10052143-20100331-149.pdf","filesize":[{"value":"419.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10052143-20100331-149.pdf","url":"https://dwcla.repo.nii.ac.jp/record/709/files/AN10052143-20100331-149.pdf"},"version_id":"b745bff8-6157-4af6-9788-8f67d8a0efa8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"キノン型多環芳香族炭化水素による活性酸素種の生成とNF-κBの活性化およびシクロオキシゲナーゼ-2の誘導発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"キノン型多環芳香族炭化水素による活性酸素種の生成とNF-κBの活性化およびシクロオキシゲナーゼ-2の誘導発現"}]},"item_type_id":"10002","owner":"15","path":["21","230"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-31"},"publish_date":"2010-03-31","publish_status":"0","recid":"709","relation_version_is_last":true,"title":["キノン型多環芳香族炭化水素による活性酸素種の生成とNF-κBの活性化およびシクロオキシゲナーゼ-2の誘導発現"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-05-16T03:33:30.977375+00:00"}