{"created":"2023-05-15T14:05:48.972909+00:00","id":640,"links":{},"metadata":{"_buckets":{"deposit":"f9bc9f94-6e15-4975-a492-f74c8a774e05"},"_deposit":{"created_by":15,"id":"640","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"640"},"status":"published"},"_oai":{"id":"oai:dwcla.repo.nii.ac.jp:00000640","sets":["20:21","224:226"]},"author_link":["555","1595","1594","782","1201","445"],"item_10002_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Two compartment model based PK (TCBPK) method for dynamo-PK analysis : simulation of food effects on PK of propranolol"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"117","bibliographicPageStart":"109","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"総合文化研究所紀要"},{"bibliographic_title":"Bulletin of The Institute for Interdisciplinary Studies of Culture Doshisha Women's College of Liberal Arts","bibliographic_titleLang":"en"}]}]},"item_10002_description_35":{"attribute_name":"ID","attribute_value_mlt":[{"subitem_description":"AN10052143-20060331-109","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　For analysis of pharmacokinetics (PK) corresponding to time-dependent-changes in the physiological conditions such as hepatic blood low (Qh) and hepatic availability  (Fh) (dynamo PK), a two-compartment-model based PK (TCBPK) analysis method was derived, in which one of common PK parameters, Clt[=Qh (1-Fh)] was assumed to be variable with time. In order to verify it, the increase of AUC (AUCoral) in response to transient-increase in Qh after oral administration of propranolol with food was simulated.\n　The assumption of five series of sinusoidal compartments in multi-compartment model (MCM) for hepatic extraction kinetics and linear hepatic elimination afforded us a good simulation of the food effects. It was suggested that the increase in the AUCoral by food was due largely to the reduction of the first-pass effects by the transient increase in Qh.\n　This method might be useful for prediction of dynamo PK of general drugs in response to the patho-physiological changes in the functions of the liver and the kidney or common metabolism-based drug-drug interactions.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"論文 (Article)","subitem_description_type":"Other"}]},"item_10002_link_30":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_link_text":"同志社女子大学研究者データベース - 伊賀勝美","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2691/2691_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 喜里山暁子","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2711/2711_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 本保亜希乃","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2709/2709_Researcher.html"}]},"item_10002_publisher_32":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_publisher":"京都"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社女子大学総合文化研究所 (学術研究推進センター)"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"40015266085","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10052143","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09100105","subitem_source_identifier_type":"ISSN"}]},"item_10002_text_27":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"同志社女子大学薬学部医療薬学科"},{"subitem_text_value":"同志社女子大学薬学部医療薬学科"},{"subitem_text_value":"同志社女子大学薬学部医療薬学科"}]},"item_10002_text_28":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy"},{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy"},{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊賀, 勝美"},{"creatorName":"イガ, カツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"445","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185554","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185554"}]},{"creatorNames":[{"creatorName":"喜里山, 暁子"},{"creatorName":"キリヤマ, アキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"555","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005184126","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005184126"},{"nameIdentifier":"00234401","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000000234401/"}]},{"creatorNames":[{"creatorName":"本保, 亜希乃"},{"creatorName":"ホンボ, アキノ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"782","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000010285940","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000010285940"}]},{"creatorNames":[{"creatorName":"IGA, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KIRIYAMA, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1594","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HONBO, Akino","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1595","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Twoコンパートメント・ファーマコキネティック・モデル (TCBPK) を用いたダイナモPK解析 : プロプラノロールの動態に及ぼす食事の効果のシミュレーション","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Twoコンパートメント・ファーマコキネティック・モデル (TCBPK) を用いたダイナモPK解析 : プロプラノロールの動態に及ぼす食事の効果のシミュレーション"}]},"item_type_id":"10002","owner":"15","path":["21","226"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-03-31"},"publish_date":"2006-03-31","publish_status":"0","recid":"640","relation_version_is_last":true,"title":["Twoコンパートメント・ファーマコキネティック・モデル (TCBPK) を用いたダイナモPK解析 : プロプラノロールの動態に及ぼす食事の効果のシミュレーション"],"weko_creator_id":"15","weko_shared_id":15},"updated":"2023-05-15T14:49:37.706447+00:00"}