{"created":"2023-05-15T14:05:40.984973+00:00","id":441,"links":{},"metadata":{"_buckets":{"deposit":"305a2d28-caf9-46ba-ba05-f5ba9ebf9e07"},"_deposit":{"created_by":15,"id":"441","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"441"},"status":"published"},"_oai":{"id":"oai:dwcla.repo.nii.ac.jp:00000441","sets":["185:199","20:21"]},"author_link":["555","1595","1594","556","1201","445"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12-25","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"113","bibliographicPageStart":"105","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"同志社女子大學學術研究年報"},{"bibliographic_title":"Doshisha Women's College of Liberal Arts annual reports of studies","bibliographic_titleLang":"en"}]}]},"item_10002_description_19":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10002_description_35":{"attribute_name":"ID","attribute_value_mlt":[{"subitem_description":"AN0016561X-20061225-105","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The analysis of hepatic availability or hepatic extraction ratio as a function of hepatic blood flow and intrinsic clearance is important to estimate first-pass effects and oral bioavailability for pre-systemically-eliminating drugs. The dispersion model can afford more accurate analysis of hepatic availability than the other conventional models (well-stirred model, parallel-tube model). However, the model is rather complicate. In the present study, a simpler model was derived by assuming the sinusoidal space in the liver as a number of well-stirred compartments sequentially connected through the hepatic blood flow (multi-sinusoidal compartment model). In comparison with the other models, this model demonstrated hepatic outflow profiles very similar to those obtained by the dispersion model. It gave a simpler equation for hepatic availability, and improved the inaccuracy of the well-stirred model or the parallel tube model. The number of compartments, around 3, for this model corresponded to the dispersion number, 0.33, which has been reported to give the best fit to the rat hepatic outflow in the dispersion model. Similarly, the number of compartments, around 5 corresponded to the dispersion number, 0.17, which has been reported to give the best fit to the human hepatic elimination kinetics in the dispersion model.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"論文 (Article)","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15020/00000434","subitem_identifier_reg_type":"JaLC"}]},"item_10002_link_30":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_link_text":"同志社女子大学研究者データベース - 伊賀勝美","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2691/2691_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 喜里山暁子","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2711/2711_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 本保亜季乃","subitem_link_url":"http://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2709/2709_Researcher.html"}]},"item_10002_publisher_32":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_publisher":"京都"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社女子大学学術研究推進センター"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0016561X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04180038","subitem_source_identifier_type":"ISSN"}]},"item_10002_text_27":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"同志社女子大学薬学部医療薬学科"},{"subitem_text_value":"同志社女子大学薬学部医療薬学科"},{"subitem_text_value":"同志社女子大学薬学部医療薬学科"}]},"item_10002_text_28":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences"},{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences"},{"subitem_text_value":"Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences"}]},"item_10002_text_29":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"Author"},{"subitem_text_value":"Collaborator"},{"subitem_text_value":"Collaborator"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊賀, 勝美"},{"creatorName":"イガ, カツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"445","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185554","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185554"}]},{"creatorNames":[{"creatorName":"喜里山, 暁子"},{"creatorName":"キリヤマ, アキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"555","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005184126","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005184126"},{"nameIdentifier":"00234401","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000000234401/"}]},{"creatorNames":[{"creatorName":"本保, 亜季乃"},{"creatorName":"ホンボ, アキノ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IGA, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KIRIYAMA, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1594","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HONBO, Akino","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1595","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-08-03"}],"displaytype":"detail","filename":"AN0016561X-20061225-105.pdf","filesize":[{"value":"689.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN0016561X-20061225-105.pdf","url":"https://dwcla.repo.nii.ac.jp/record/441/files/AN0016561X-20061225-105.pdf"},"version_id":"161ef847-65e9-4d83-a5a1-02f885dffa87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatic availability","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatic extraction ratio","subitem_subject_scheme":"Other"},{"subitem_subject":"intrinsic clearance","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatic blood flow","subitem_subject_scheme":"Other"},{"subitem_subject":"total body clearance","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatic outflow","subitem_subject_scheme":"Other"},{"subitem_subject":"well-stirred model","subitem_subject_scheme":"Other"},{"subitem_subject":"parallel tube model","subitem_subject_scheme":"Other"},{"subitem_subject":"dispersion model","subitem_subject_scheme":"Other"},{"subitem_subject":"multi-sinusoidal compartment model","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A multi-sinusoidal compartment model as an alternative to the dispersion model for hepatic extraction kinetic analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multi-sinusoidal compartment model as an alternative to the dispersion model for hepatic extraction kinetic analysis"}]},"item_type_id":"10002","owner":"15","path":["21","199"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-12-25"},"publish_date":"2006-12-25","publish_status":"0","recid":"441","relation_version_is_last":true,"title":["A multi-sinusoidal compartment model as an alternative to the dispersion model for hepatic extraction kinetic analysis"],"weko_creator_id":"15","weko_shared_id":15},"updated":"2023-05-15T14:49:30.437799+00:00"}