{"created":"2023-05-15T14:06:58.764828+00:00","id":2381,"links":{},"metadata":{"_buckets":{"deposit":"53d1396b-076b-433a-a0c3-0e999f597636"},"_deposit":{"created_by":19,"id":"2381","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"2381"},"status":"published"},"_oai":{"id":"oai:dwcla.repo.nii.ac.jp:00002381","sets":["20:21","224:379"]},"author_link":["7123","7121","7125","7122","7126","7124"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-29","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"129","bibliographicPageStart":"118","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"総合文化研究所紀要"},{"bibliographic_title":"Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts","bibliographic_titleLang":"en"}]}]},"item_10002_description_19":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10002_description_35":{"attribute_name":"ID","attribute_value_mlt":[{"subitem_description":"AN10052143-20220729-118","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dacarbazine is a therapeutic agent for melanoma of alkylating anti-tumor agents. In this study, we examined its pharmacokinetic characteristics using experimental animals and investigated using various pharmacokinetic model analysis methods. The pharmacokinetic behavior of the drug can be simulated in the various treatment routes and/or schedules and provide basic information on medical treatment.\nThe pharmacokinetics of dacarbazine followed a 2-compartment pharmacokinetic model, namely some organs being rapidly distributed and some organs taking a long time, resulting in a relatively large volume of distribution. No accumulation of dacarbazine was observed in the body after intravenous administration once daily for 5 days, which is the standard treatment schedule in clinical practice. It shows effective pharmacokinetics as drugs with a concentration-dependent effect.\nDacarbazine is usually administered rapidly intravenous bolus or by iv infusion, though it is considered that dacarbazine shows similar pharmacokinetics and is effective even in the extravascular route where rapid absorption, with an absorption rate constant (ka) of about 0.5 min-1 or more, can be obtained.\nUsing the pharmacokinetic modeling technique, it is possible to predict the pharmacokinetics when administered under various conditions, and further to predict the degree of effect onset and the time transition (duration) of the effect. In addition, by proceeding with the study, it is possible to estimate how the pharmacokinetics will change and how the effects of the drug will be affected when combination therapy is given as compared to monotherapy. Similarly, when physiological conditions change, such as age and pathological condition, the outcome of drug therapy is estimated by how the pharmacokinetics and drug effects are affected or hardly affected.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15020/00002317","subitem_identifier_reg_type":"JaLC"}]},"item_10002_link_30":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_link_text":"同志社女子大学研究者データベース - 喜里山暁子","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2711/2711_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース -山下修吾","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/4287/4287_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース -木村峻輔","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/3876/3876_Researcher.html"}]},"item_10002_publisher_32":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_publisher":"京都"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社女子大学総合文化研究所 (学術研究支援課)"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10052143","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09100105","subitem_source_identifier_type":"ISSN"}]},"item_10002_text_27":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科・准教授"},{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科・特別任用助教（有期）"},{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科・特別任用助教（有期）"}]},"item_10002_text_28":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Associate professor"},{"subitem_text_value":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Assistant professor (contract)"},{"subitem_text_value":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Assistant professor (contract)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"喜里山, 暁子"},{"creatorName":"キリヤマ, アキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下, 修吾"},{"creatorName":"ヤマシタ, シュウゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 峻輔"},{"creatorName":"キムラ, シュンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KIRIYAMA, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMASHITA, Shugo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KIMURA, Shunsuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7126","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-13"}],"displaytype":"detail","filename":"AN10052143-20220729-118.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"抗悪性腫瘍薬・ダカルバジンのラットを用いた薬物動態学的モデル解析の基礎的検討","url":"https://dwcla.repo.nii.ac.jp/record/2381/files/AN10052143-20220729-118.pdf"},"version_id":"ced98ffc-696a-484f-af5d-deee548bd51c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-cancer agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dacarbazine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetic modeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗悪性腫瘍薬・ダカルバジンのラットを用いた薬物動態学的モデル解析の基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗悪性腫瘍薬・ダカルバジンのラットを用いた薬物動態学的モデル解析の基礎的検討"},{"subitem_title":"Basic study of pharmacokinetic model analysis of anti-cancer agent, dacarbazine, using rats","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"19","path":["21","379"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-13"},"publish_date":"2023-01-13","publish_status":"0","recid":"2381","relation_version_is_last":true,"title":["抗悪性腫瘍薬・ダカルバジンのラットを用いた薬物動態学的モデル解析の基礎的検討"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T14:16:20.673876+00:00"}