WEKO3
アイテム
ラットを用いた抗糖尿病薬・グリメピリドと抗脂血症薬・ベザフィブラートの併用効果―薬物動態学／薬力学解析を用いた基礎的検討―
https://doi.org/10.15020/0002000653
https://doi.org/10.15020/000200065349617643-1a5c-4da6-98f9-5ba5dfab6cbb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN10052143-20240729-45.pdf (1.2 MB)
|
|
| アイテムタイプ | デフォルトアイテムタイプ（フル）(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2026-03-10 | |||||
| タイトル | ||||||
| タイトル | ラットを用いた抗糖尿病薬・グリメピリドと抗脂血症薬・ベザフィブラートの併用効果―薬物動態学／薬力学解析を用いた基礎的検討― | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Combination effects of an antidiabetic glimepiride and an antilipidemic bezafibrate in rats ― Basic study using pharmacokinetic/pharmacodynamic analysis ― | |||||
| 言語 | en | |||||
| 作成者 |
喜里山, 暁子
× 喜里山, 暁子× 山下, 修吾× 木村, 峻輔 |
|||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hypertension, diabetes, and dyslipidemia are lifestyle-related diseases caused by longstanding lifestyle habits. In addition, when these diseases coexist, the intake of multiple medications is necessary, which increases the potential for drug interactions. We have already analyzed and quantitatively elucidated the relationship between the pharmacokinetics and hypoglycemic effects of antidiabetic glimepiride. This study focuses on the hypoglycemic effects of glimepiride and the antilipidemic bezafibrate in combination, and conducts basic investigations on their pharmacokinetics and effects in rats. Regarding the pharmacokinetic characteristics of bezafibrate, it was found that, its terminal half-life (t1/2) is longer, its total body clearance (CLtot) is lower, and its mean residence time (MRT) is longer, indicating prolonged retention in the body compared with glimepiride. Additionally, when both drugs were co-administered, the pharmacokinetics of glimepiride remained largely unchanged despite an extension in its t1/2. When bezafibrate was administered separately, it exhibited a similar degree of hypoglycemic effect as the control group and lasted approximately 60-120 minutes after administration. In the case of co-administration, the hypoglycemic effect of glimepiride was almost the same as that of glimepiride separately. This result possibly reflects the hypoglycemic effect of the co-administration. Although no significant fluctuations were observed in the hypoglycemic effect when both drugs were used concurrently, co-administration led to an increase in the tissue distribution of bezafibrate. This suggests that the long-term efficacy of bezafibrate may have been affected. As this effect takes approximately one week to manifest, unlike the hypoglycemic effect, it will be necessary to consider it in future long-term plans. |
|||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 同志社女子大学総合文化研究所 (学術研究支援課) | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | ドウシシャ ジョシ ダイガク ソウゴウ ブンカ ケンキュウジョ ガクジュツ ケンキュウ シエンカ | |||||
| 言語 | ja-Kana | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.15020/0002000653 | |||||
| ID登録タイプ | JaLC | |||||
| 収録物識別子 | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 09100105 | |||||
| 収録物識別子 | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10052143 | |||||
| 書誌情報 |
ja : 総合文化研究所紀要 en : Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts 巻 41, p. 45-56, 発行日 2024-07-29 |
|||||
