@article{oai:dwcla.repo.nii.ac.jp:00001806,
 author = {成橋, 和正 and 芝田, 信人 and Naruhashi, Kazumasa and Shibata, Nobuhito},
 journal = {総合文化研究所紀要, Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts},
 month = {Jul},
 note = {application/pdf, AN10052143-20200605-128, Dissolution test is mandatory to guarantee the quality of the generic pharmaceutical tablets, and generic pharmaceutical tablets must comply with this dissolution test to be approved. However, in this test, it is not clear what type of elution behavior to take, only by
specifying the dissolution rate at a fixed time. In this study, we aimed to clarify elution behavior of loxoprofen sodium 60 mg tablet (24 items) and nitrendipine 5 mg tablet (15 items) by measuring dissolution rate with time according to dissolution test of the Japanese
Pharmacopeia with some modification. Both drug showed good dissolution. The original brand loxoprofen tablets had comparatively small variation among tablets in elution behavior. For generic loxoprofen tablets, some of the dissolution rates were faster or slower. In some generic items, variations in elution behaviors were observed within the same item. In the original brand nitrendipine tablets, elution behavior showed slowly until 5 minutes, and then fast elution, and there was variation between the tablets by 15 minutes. Many of generic
nitrendipine tablets showed variations in 5 to 15 minutes in elution behavior within the same item, but some showed little variations between tablets within the same item., 論文},
 pages = {128--136},
 title = {先発医薬品・後発医薬品（錠剤）の溶出挙動の比較と評価},
 volume = {35},
 year = {2018},
 yomi = {ナルハシ, カズマサ and シバタ, ノブヒト}
}