{"created":"2023-05-15T14:06:32.069104+00:00","id":1736,"links":{},"metadata":{"_buckets":{"deposit":"75f9e972-cb46-461b-9abd-eb639b6d72e9"},"_deposit":{"created_by":19,"id":"1736","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"1736"},"status":"published"},"_oai":{"id":"oai:dwcla.repo.nii.ac.jp:00001736","sets":["185:334","20:21"]},"author_link":["5971","5972","5968","5969","5970"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-26","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"132","bibliographicPageStart":"127","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"同志社女子大學學術研究年報"},{"bibliographic_title":"Doshisha Women's College of Liberal Arts annual reports of studies","bibliographic_titleLang":"en"}]}]},"item_10002_description_19":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10002_description_35":{"attribute_name":"ID","attribute_value_mlt":[{"subitem_description":"AN0016561X-20190930-127","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A patient was given generic itraconazole (ITCZ) tablet, brand-name-ITCZ capsule, ITCZ oral solution and ITCZ injection to treat pulmonary aspergillosis. We monitored concentrations of ITCZ and its active metabolite hydroxy-ITCZ (OH-ITCZ) in plasma and lung tissues. During administration of the generic product (400 mg/day), trough plasma concentrations of ITCZ and OH-ITCZ were 76 ng/mL and 126 ng/mL, respectively. After administration of the brand-name product (200 mg/day), they increased to 229 ng/mL and 540 ng/mL, respectively. ITCZ and OH-ITCZ concentrations/dosage ratios were 6.1 and 8.4 times higher by switching to the brand-name product, respectively. It was suggested that there may be a difference in pharmacokinetics between the brand-name ITCZ and the generic. Also, we determined ITCZ and OH-ITCZ concentrations infected and uninfected tissues of resected lung simultaneously. The ITCZ concentration in the infected lesion of the lung was approximately 2.3 times higher than that in plasma and 1.6 times higher than in uninfected lung tissue. The OH-ITCZ concentration in the infected lesion was higher than ITCZ in the same region. It was considered that the high concentrations of ITCZ and its metabolite at infected lesion were due to their high affinities with ergosterol in fungal membrane.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究ノート","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15020/00001695","subitem_identifier_reg_type":"JaLC"}]},"item_10002_link_30":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_link_text":"同志社女子大学研究者データベース - 松元加奈","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2948/2948_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 森田邦彦","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2696/2696_Researcher.html"}]},"item_10002_publisher_32":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_publisher":"京田辺"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社女子大学学術情報部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0016561X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04180038","subitem_source_identifier_type":"ISSN"}]},"item_10002_text_27":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科"},{"subitem_text_value":"同志社女子大学・大学院薬学研究科医療薬学専攻・大学院生　独立行政法人国立病院機構・南京都病院薬剤部・薬剤師"},{"subitem_text_value":"独立行政法人国立病院機構・南京都病院呼吸器科・診療部長"},{"subitem_text_value":"独立行政法人国立病院機構・南京都病院呼吸器外科・呼吸器外科医長"},{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科"}]},"item_10002_text_28":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences,Doshisha Women's College of Liberal Arts"},{"subitem_text_value":"Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences Clinical Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Graduate student/Department of Pharmacy, National Hospital Organization Minami-Kyoto Hospital, Pharmacist"},{"subitem_text_value":"Department of Respiratory Medicine, National Hospital Organization Minami-Kyoto Hospital, Consultant"},{"subitem_text_value":"Department of Thoracic Surgery, National Hospital Organization Minami-Kyoto Hospital, Chief surgeon"},{"subitem_text_value":"Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Professor"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松元, 加奈"},{"creatorName":"マツモト, カナ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Kana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5968","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002748633","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002748633"},{"nameIdentifier":"20469084","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000020469084/"}]},{"creatorNames":[{"creatorName":"仲村, 弥栄子"},{"creatorName":"ナカムラ, ヤエコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Yaeko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5969","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018813813","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018813813"}]},{"creatorNames":[{"creatorName":"佐藤, 敦夫"},{"creatorName":"サトウ, アツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Atsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5970","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000387478824","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000387478824"}]},{"creatorNames":[{"creatorName":"朝倉, 庄志"},{"creatorName":"アサクラ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Asakura, Shoji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5971","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002874639","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002874639"}]},{"creatorNames":[{"creatorName":"森田, 邦彦"},{"creatorName":"モリタ, クニヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Morita, Kunihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5972","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100008032771","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/100008032771"},{"nameIdentifier":"80327717","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000080327717/"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-01"}],"displaytype":"detail","filename":"AN0016561X-20190930-127.pdf","filesize":[{"value":"469.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"肺アスペルギルス症患者におけるイトラコナゾールおよび","url":"https://dwcla.repo.nii.ac.jp/record/1736/files/AN0016561X-20190930-127.pdf"},"version_id":"8cf742a6-faa8-413c-957b-475b013f4b5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"itraconazole","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydroxy-itraconazole","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"generic drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary aspergillosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肺アスペルギルス症患者におけるイトラコナゾールおよび","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺アスペルギルス症患者におけるイトラコナゾールおよび"},{"subitem_title":"Blood and Lung Concentrations of Itraconazole and its Active Metabolite in Patients with Pulmonary Aspergillosis","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"19","path":["21","334"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-30"},"publish_date":"2019-09-30","publish_status":"0","recid":"1736","relation_version_is_last":true,"title":["肺アスペルギルス症患者におけるイトラコナゾールおよび"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T14:42:01.786528+00:00"}