{"created":"2023-05-15T14:06:31.830570+00:00","id":1731,"links":{},"metadata":{"_buckets":{"deposit":"6bef785b-22c4-49ed-8530-2fd4cab3691a"},"_deposit":{"created_by":19,"id":"1731","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"1731"},"status":"published"},"_oai":{"id":"oai:dwcla.repo.nii.ac.jp:00001731","sets":["185:334","20:21"]},"author_link":["5963","5960","5961","5964","5962","5965"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-26","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"66","bibliographicPageStart":"59","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"同志社女子大學學術研究年報"},{"bibliographic_title":"Doshisha Women's College of Liberal Arts annual reports of studies","bibliographic_titleLang":"en"}]}]},"item_10002_description_19":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10002_description_35":{"attribute_name":"ID","attribute_value_mlt":[{"subitem_description":"AN0016561X-20190930-59","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アセチルコリン（ACh）は、最も古くから知られている神経伝達物質である。しかしながら、AChはリンパ系細胞でも産生され、種々のサイトカイン産生やナィーブT細胞の分化に影響を及ぼして免疫機能調節に関与していることが明らかになっている。ナマコ（sea cucumber）由来の抽出成分IJ-337には、サイトカイン産生抑制作用、神経性疼痛抑制作用や糖尿病性知覚異常改善作用などがあることが報告されている。本研究では、IJ-337のTリンパ球機能およびTリンパ球コリン作動系活性に及ぼす影響について検討した。T細胞のモデルとしてヒトT細胞系白血病細胞株MOLT-3を用いた。IJ-337は、MOLT-3細胞における転写調節因子c-fos遺伝子発現を抑制した。さらに、IJ-337は、インターロイキン-2 (IL-2) タンパク質産生量を減少させた。しかしながら、IJ-337はTリンパ球コリン作動系活性には影響を及ぼさなかった。IJ-337はMOLT-3細胞の増殖を抑制した。以上の結果より、IJ-337はコリン作動系には影響を与えることなく，T細胞機能を抑制して免疫活性を抑制する可能性が示唆された。\n\nAcetylcholine (ACh) is the oldest known neurotransmitter. However, ACh is also present in lymphoid cells, and it has been clarified that it is involved in the regulation of immune function through regulation of various cytokine expression and differentiation of naive T cells. It has been reported that extractive component, IJ - 337 derived from sea cucumber has an inhibitory effect on cytokine expression, anti-diabetic action and anti-inflammatory action. In this study, we investigated the effect of IJ-337 on T lymphocyte function and T lymphocyte cholinergic system activity. A human T cell lineage leukemia cell line MOLT-3 was used as a model of T cells. IJ-337 suppressed transcription regulatory factor c-fos gene expression in MOLT-3 cells. In addition, IJ-337 decreased interleukin-2 (IL-2) protein production. However, IJ-337 did not affect T lymphocyte cholinergic system activity. IJ-337 suppressed proliferation of MOLT-3 cells. These\nresults suggested that IJ-337 could suppress immune activity by suppressing T cell function, regardless of T lymphocyte cholinergic system.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15020/00001690","subitem_identifier_reg_type":"JaLC"}]},"item_10002_link_30":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_link_text":"同志社女子大学研究者データベース - 間下雅士","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/3633/3633_Researcher.html"},{"subitem_link_text":"同志社女子大学研究者データベース - 藤井健志","subitem_link_url":"https://research-db.dwc.doshisha.ac.jp/rd/html/japanese/researchersHtml/2703/2703_Researcher.html"}]},"item_10002_publisher_32":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_publisher":"京田辺"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"同志社女子大学学術情報部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0016561X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04180038","subitem_source_identifier_type":"ISSN"}]},"item_10002_text_27":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科"},{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科"},{"subitem_text_value":"イメックスジャパン株式会社"},{"subitem_text_value":"北里大学・薬学部"},{"subitem_text_value":"同志社女子大学・薬学部・医療薬学科"}]},"item_10002_text_28":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Pharmacology, Faculty of Pharmaceutical Sciences,Doshisha Women’s College of Liberal Arts"},{"subitem_text_value":"Department of Pharmacology, Faculty of Pharmaceutical Sciences,Doshisha Women’s College of Liberal Arts"},{"subitem_text_value":"Imex Japan, Co., LTD."},{"subitem_text_value":"Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences"},{"subitem_text_value":"Department of Pharmacology, Faculty of Pharmaceutical Sciences,Doshisha Women’s College of Liberal Arts"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"間下, 雅士"},{"creatorName":"マシモ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Mashimo, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5960","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000387478518","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000387478518"},{"nameIdentifier":"30738886","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000030738886/"}]},{"creatorNames":[{"creatorName":"金取, 里美"},{"creatorName":"カナトリ, サトミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanatori, Satomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5961","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000387478519","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000387478519"}]},{"creatorNames":[{"creatorName":"フーワー, フォン"}],"nameIdentifiers":[{"nameIdentifier":"5962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川島, 紘一郎"},{"creatorName":"カワシマ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawashima, Koichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5963","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070095008","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000070095008"},{"nameIdentifier":"70095008","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000070095008/"}]},{"creatorNames":[{"creatorName":"藤井, 健志"},{"creatorName":"フジイ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujii, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5964","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080255380","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080255380"},{"nameIdentifier":"80255380","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000080255380/"}]},{"creatorNames":[{"creatorName":"Foo Wah, Foong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5965","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-01"}],"displaytype":"detail","filename":"AN0016561X-20190930-59.pdf","filesize":[{"value":"631.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ナマコ由来成分IJ-337のT細胞の機能とコリン作動系活性に及ぼす影響","url":"https://dwcla.repo.nii.ac.jp/record/1731/files/AN0016561X-20190930-59.pdf"},"version_id":"b3bb9280-b478-49bf-817e-7a8e246f0f23"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acetylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-fos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IJ-337","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ナマコ由来成分IJ-337のT細胞の機能とコリン作動系活性に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ナマコ由来成分IJ-337のT細胞の機能とコリン作動系活性に及ぼす影響"},{"subitem_title":"Effects of IJ-337 Derived from a Sea Cucumber on T-cell Function and the Lymphocytic Cholinergic System","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"19","path":["21","334"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-30"},"publish_date":"2019-09-30","publish_status":"0","recid":"1731","relation_version_is_last":true,"title":["ナマコ由来成分IJ-337のT細胞の機能とコリン作動系活性に及ぼす影響"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-05-15T14:42:17.713769+00:00"}